Description
Product Characteristics:
Aliases: Caspr antibody, Caspr1 antibody, CNTNAP antibody, Cntnap1 antibody, CNTP1_HUMAN antibody, Contactin associated protein 1 antibody, Contactin-associated protein 1 antibody, MHDNIV antibody, NCP1 antibody, Neurexin 4 antibody, Neurexin IV antibody, Neurexin-4 antibody, Nrxn4 antibody, p190 antibody, Paranodin antibody
Target Information: The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]